Korean J Obstet Gynecol Search


Korean Journal of Obstetrics & Gynecology 2005;48(10):2367-2376.
Published online October 1, 2005.
Clinical Efficacy of Low-dose Aspirin and Prednisolone in Controlled Ovarian Hyperstimulation for In Vitro Fertilization and Embryo Transfer.
Yong Jin Kim, Chae Hyung Lee, Seung Su Han, Young Sik Choi, Jeong Ryeol Lee, Byung Chul Jee, Seung Yup Ku, Chang Suk Suh, Young Min Choi, Jung Gu Kim, Shin Yong Moon, Seok Hyun Kim
1Department of Obstetrics and Gynecology, College of Medicine, Medical Research Center, Seoul National University, Seoul, Korea. seokhyun@snu.ac.kr
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
To determine whether the use of low-dose aspirin and prednisolone in controlled ovarian hyperstimulation (COH) with GnRH agonist long protocol improves the outcomes of in vitro fertilization and embryo transfer (IVF-ET). METHODS: Two hundred and forty IVF-ET cycles were assigned to four groups: control group (aspirin(-) and prednisolone(-), n=59), low-dose aspirin group (aspirin(+) and prednisolone(-), n=43, Group 1), prednisolone group (aspirin(-) and prednisolone(+), n=80, Group 2), and low-dose aspirin and prednisolone group (aspirin(+) and prednisolone(+), n=58, Group 3). The COH and pregnancy outcomes were retrospectively compared among the four groups. RESULTS: Group 1 showed higher fertilization rate with a borderline significance compared to control group (73.6% vs. 64.1%, p=0.050). Serum estradiol (E2) level on hCG day was 995.5+/-767.5 pg/mL in control group, 1,550.7+/-1,254.5 pg/mL in group 1, 1,469.2+/-1,206.6 pg/mL in group 2 and 1,796.0+/-1,548.0 pg/mL in group 3 and higher in the three treatment groups compared to control (p=0.012, p=0.006, p<0.001, respectively). Embryo score per transferred embryo was also higher in Group 1 (17.4+/-8.4, p=0.001) and 3 (16.0+/-6.1, p<0.001) compared to control (12.2+/-5.1). There were no significant differences in the implantation and the pregnancy rates among the four groups. CONCLUSION: The use of low-dose aspirin or prednisolone may be beneficial in IVF-ET patients undergoing COH with GnRH agonist long protocol. Further larger-scale prospective randomized investigations are necessary to confirm these findings.
Key Words: IVF-ET, COH, Low-dose aspirin, Prednisolone

Article category

Browse all articles >


Browse all articles >

Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea.
Tel: +82-2-2266-7238    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2024 by Korean Society of Obstetrics and Gynecology.

Developed in M2PI

Close layer
prev next