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Korean Journal of Obstetrics & Gynecology 2005;48(11):2493-2509.
Published online November 1, 2005.
Recent Trends in Preimplantation Genetic Diagnosis (PGD).
Jin Yeong Kim, Inn Soo Kang
Department of Obstetrics and Gynecology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. ikang67@yahoo.co.kr
Abstract
Preimplantation genetic diagnosis (PGD) provides practical option to prevent the termination of pregnancy and miscarriage in couples with high risk of genetic disease or recurrent spontaneous abortion. In balanced chromosomal translocation, PGD can reduce the abortion rate and with PGD for aneuploidy screening, higher implantation rate and lower abortion rate can be obtained in patients with poor reproductive prognosis. Therefore PGD is widely used in ART for improving IVF efficiency. With technical development in single cell, such as FISH, PCR, CGH and microarray, the indications have expanded beyond the monogenic disease and chromosome aberration, as late-onset disease or HLA matching for stem cell donor.
Key Words: Preimplantation genetic diagnosis, Monogenic disorder, Chromosome, Translocation, Aneuploidy, FISH, PCR


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