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Korean Journal of Obstetrics & Gynecology 2005;48(11):2661-2669.
Published online November 1, 2005.
Relationship between the Expression of COX-1, COX-2, p53 and VEGF and Prognostic factors in Squamous cell carcinoma of Uterine cervix.
Jong Kil Joo, Dong Hyung Lee, Ki Hyung Kim, Yong Jin Na, Chang Hoon Lee, Man Soo Yoon
1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@pusan.ac.kr
2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.
Abstract
OBJECTIVE
The aim of this study was to examine that COX-1, COX-2, p53 and VEGF expression are associated with prognostically worse pathological variables and to investigate whether the enhanced COX-2, tumor microvessel density and VEGF expression is showed in invasive cervical cancer. METHODS: From January 1998 to December 2001, sixty-three cases of paraffin-embedded cervical specimens were obtained by surgical resection in the Pusan National University Hospital. All tissues were subjected to immunohistochemical staining for COX-1, COX-2, p53, VEGF and microvessel density. Clinical factors such as age, FIGO stage and pelvic lymph node metastasis were evaluated. RESULTS: In COX-1 expression, no staining and cells staining positive less than 10% were 49, 13 cases, respectively. In contrast, COX-2 expressions was demonstrated in the cells staining positive 10% to 50% and greater than 50% were 25, 17 cases, respectively. The positivities of p53 and VEGF were 68.3% (43/63), 77.8% (49/63), respectively. There was a significant correlation between COX-2 and VEGF expression (p<0.05) in cervical cancer. Also the relationship existed between VEGF and microvessel count. But there was no correlation between COX-2, microvessel count and clinicopathologic factors in cervical cancer. CONCLUSION: These findings provide evidence that the expression of COX-2 and VEGF may be involved in the promotion of angiogenesis in cervical cancer.
Key Words: COX-1, COX-2, VEGF, Cervical cancer


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