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Korean Journal of Obstetrics & Gynecology 2005;48(12):2903-2909.
Published online December 1, 2005.
Adenosine 5'-triphosphate induced NF-kappa B and intracellular calcium mobilization in cervical cancer cells.
Dae Seog Lim, Su Mi Bae, Sun Young Kwak, Guo Hua Ding, Jeong Kim, Yong Wook Kim, Duck Yeong Ro, Joon Mo Lee, Seung Eun Namkoong, Young Lae Cho, Sei Jun Han, Gye Hyun Nam, Byung Don Han, Chong Kook Kim, Woong Shick Ahn
1Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea.
2Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea. ahnws@catholic.ac.kr
3Department of Obstetrics and Gynecology, College of Medicine, Kyungbook National University, Taegu, Korea.
4Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea.
5Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Korea.
6Koma Biotech, Seoul, Korea.
7College of Pharmacy, Seoul National University, Korea.
Abstract
OBJECTIVE
To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells. METHODS: Study design: Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines. RESULTS: Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappa B in all cell lines used. CONCLUSION: These results suggest that calcium mobilization and NF-kappa B dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
Key Words: ATP, Cervical cancer cells, Calcium mobilization, Proliferation, NF-kappa B


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