A Case of Non-Hodgkin Lymphoma during Pregnancy.

Park, Hye Eun; Lee, Chun June; Kim, Chung Hoon

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Korean Journal of Obstetrics & Gynecology 2006;49(1):230-235.
Published online January 1, 2006.

A Case of Non-Hodgkin Lymphoma during Pregnancy.

Hye Eun Park, Chun June Lee, Chung Hoon Kim

¹Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea. l1000jun@naver.com
²Department of Surgery, College of Medicine, Kosin University, Busan, Korea.

Abstract

The occurrence of Non-Hodgkin's lymphoma (NHL) during pregnancy is very rare and this malignancy is most commonly associated with aggressive histology and dissemination. Treatment in pregnant women with low-grade lymphoma may be delayed until after delivery but women with an aggressive lymphoma must have a immediate initiation of standard chemotherapy whether to have a therapeutic abortion or not. A-32-year-old woman with NHL stage IIb complicating pregnancy is presented. The diagnosis was made aggressive lymphoma. The baby weighting 1,830 gm was delivered by normal spontaneous vaginal delivery. Following delivery, the patient received combination chemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone regimen but magnetic resonance imaging undertaken during follow-up showed leptomeningeal involvement, indicating poor prognosis. She wanted discharge ten months later from disseminated disease. We experienced a case of rapid growing Non-Hodgkin's lymphoma developed on anterior mediastineum that diagnosed during pregnancy and treated following delivery. We report this case with a brief review of literature.

Key Words: Pregnancy, Non-Hodgkin's lymphoma

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