Clinical and cytogenetic analysis of midtrimester amniocentesis.

Kim, Hyeong Ok; Lee, Kyo Won; Kim, Kye Hyun

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Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(2):365-373.
Published online February 1, 2006.

Clinical and cytogenetic analysis of midtrimester amniocentesis.

Hyeong Ok Kim, Kyo Won Lee, Kye Hyun Kim

Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. khmd.kim@samsung.com

Abstract

OBJECTIVE
To analyze clinical data based on prenatal genetic amniocentesis. METHODS: We analyzed retrospectively maternal age, gestational age, indications, cytogenetic results and complications, based on a total of 496 cases of midtrimester prenatal genetic amniocentesis performed at Sungkyunkwan University School of Medicine, Kangbuk Samsung hospital from March 2000 to May 2005. RESULTS: The most common age of total subjects was between 35-39 years (37.1%). The indications of amniocentesis were abnormal maternal serum marker (39.72%), advanced maternal age (35.89%), abnormal ultrasonographic finding (5.04%), combined old age and abnormal maternal serum marker (4.23%), in order. Since 2000, the number of amniocentesis due to abnormal ultrasonographic finding was increased. The overall incidence of chromosomal abnormalities were 6.05% (30/496). There was no significant difference between maternal age and abnormal fetal karyotype. According to indications, there was 7.11% (14/197) of chromosomal abnormalities in abnormal maternal serum screening group, 1.69% (3/178) in advanced maternal age group and 22.22% (6/27) in abnormal ultrasonographic finding group. CONCLUSION: Abnormal maternal serum marker and advanced maternal age were the most common indication. There were frequent chromosomal abnormalities in combined old age and abnormal maternal serum marker group and abnormal ultrasonographic finding group.

Key Words: Midtrimester amniocentesis, Cytogenetics, Chromosomal abnormality

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