Clinicopathologic Analysis and Prognosis of Endodermal Sinus Tumor of the Ovary.

Jung, Min Hyung; Park, Sun Jung; Kim, Dae Yeon; Kim, Jong Hyeok; Kim, Yong Man; Kim, Young Tak; Nam, Joo Hyun; Mok, Jung Eun

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Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(3):628-632.
Published online March 1, 2006.

Clinicopathologic Analysis and Prognosis of Endodermal Sinus Tumor of the Ovary.

Min Hyung Jung, Sun Jung Park, Dae Yeon Kim, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam, Jung Eun Mok

Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. ymkim@amc.seoul.kr

Abstract

OBJECTIVE
To evaluate the clinical and pathological characteristics of endodermal sinus tumor (EST) of the ovary. METHODS: Seventeen patients who were treated with EST of the ovary between September 1991 and February 2005 were reviewed retrospectively for clinicopathologic characteristics, treatments, and outcomes. RESULTS: Median age at diagnosis was 22.0 years (range 7-43). Nine patients (52.9%) were stage I, 3 (17.6%) stage II, 4 (23.5%) stage III, and 1 (5.9%) stage IV. Twelve of 17 patients underwent conservative surgery including unilateral salpingo-oophorectomy, unilateral oophorectomy and others were underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. All patients received adjuvant combination chemotherapy. Eleven patients received BEP (bleomycin, etoposide, cisplatin) combination chemotherapy and the others received VAC (vincristine, actinomycin D, cyclophosphamide). One patient had recurred, and 3 patients had died of the disease. The mean overall survival is 153.6 months. Patients with stage I and II had a more favorable prognosis than those with stage III and IV disease (p<0.05). Patients received BEP combination chemotherapy showed significantly better prognosis than patients received VAC (p<0.05). CONCLUSION: Less advanced stage and BEP combination chemotherapy showed significantly better prognosis.

Key Words: Ovary, Endodermal sinus tumor, Prognostic factors

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