The Expression of Clusterin in Cervical Cancer tissues.

Park, Dong Choon; Shin, Eun Young; Lee, Hae Young; Kim, Dae Hoon

Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(4):840-846.
Published online April 1, 2006.

The Expression of Clusterin in Cervical Cancer tissues.

Dong Choon Park, Eun Young Shin, Hae Young Lee, Dae Hoon Kim

¹Department of Obstetrics and Gynecology, Saint Vincent Hospital, The Catholic University of Korea. dhkim2k@catholic.ac.kr
²Research Institute of Medical Science of Saint Vincent Hospital, The Catholic University of Korea.
³Department of Obstetrics and Gynecology, Shesmedi Hospital, Korea.

Abstract

OBJECTIVE
Immunohistochemistry was performed on normal and cervical cancer tissues to determine the differential expression patterns of clusterin. METHODS: Fifteen normal cervical tissues and thirty-two primary cervical cancer tissues were used. Clusterin expression was determined with immunohistochemical staining and quantified with scoring system. RESULTS: The normal cervical tissues expressed low levels of clusterin expression and their mean score was 1.35. On the contrary cervical cancer tissues showed high levels of clusterin expression with mean score, 4.08. And the difference of expression was statistically significant (P<0.05). CONCLUSION: These data suggest that clusterin expression is higher in cervical cancer tissues than normal cervical tissues.

Key Words: Clusterin, Cervical cancer