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Korean Journal of Obstetrics & Gynecology 2006;49(5):1007-1016.
Published online May 1, 2006.
Plasma sex steroid hormones and leptin levels in preeclampsia.
Ki Hyung Kim, Kyu Sup Lee
Department of Obstetrics and Gynecology, Pusan National University, College of Medicine, Busan, Korea. kuslee@pusan.ac.kr
The aim of this study was to measure maternal plasma androgens, estrogen and leptin levels and to assess the role of these hormones in the pathogenesis of preeclampsia. METHODS: The groups consisted of 32 healthy pregnant women as well as 28 pregnant women with severe preeclampsia. Plasma leptin, total testosterone (T), estradiol (E2), dehydroepiandrosterone sulfate (DHEAS) and androstenedione (ADD) levels were measured. Statistical analysis was achieved with Student's t-test by using SPSS for Windows and the Pearson's coefficient of correlation was calculated. RESULTS: No significant differences were observed between the two groups regarding age, gestational age, body mass index, parity, hematocrit and platelet, whereas significant differences were noted regarding systolic and diastolic blood pressure, gestational weeks at delivery, birth weight, serum creatinine, uric acid and urea (p<0.05). In preeclampsia group, serum total testosterone and ADD levels were determined to be higher than the control group (p<0.05). However, there was no significant differences in plasma levels of DHEAS and E2 among the two groups. The plasma levels of leptin were not significantly increased in the preeclampsia group. Serum testosterone levels were positively correlated with systolic and diastolic pressure and uric acid and negatively correlated with birth weight. CONCLUSION: These results suggest that the elevated plasma levels of testosterone could contribute to the pathogenesis of preeclampsia.
Key Words: Testosterone, Estradiol, Leptin, Preeclampsia

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