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Korean Journal of Obstetrics & Gynecology 2006;49(6):1179-1187.
Published online June 1, 2006.
Polycystic Ovary Syndrome and Insulin Resistance.
Ju Youn Hwang, Byung Seok Lee
Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. dr222@yumc.yonsei.ac.kr
Abstract
Polycysytic Ovary Syndrome (PCOS) is a common endocrine disorder characterized by chronic anovulation and hyperandrogenism. The etiology of PCOS is complex and incompletely understood. Accumulating data conclude that hyperinsulinemia and hyperandrogenemia may cause hormonal abnormalities that lead to disturbance of ovarian function. Although insulin resistance is not a part of the diagnostic criteria for PCOS, its importance in its pathogenesis can not be ignored. Excess insulin is capable of stimulating steroidogenesis and therefore excessive androgen production occurs from the theca cell system. Recently, the effects of insulin sensitizer in PCOS patients are being reported and they include the improvement of menstrual pattern, improvement in hyperandrogenism, increased response in ovulation induction and prevention of cardiovascular diseases. Understanding the relation of PCOS and insulin resistance will offer an improvement in treatment of PCOS in the future.
Key Words: Polycystic ovary syndrome, Hyperandrogenism, Insulin resistance, Insulin sensitizer


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