MTA1 expression in epithelial ovarian neoplasm.

Yoon, Man Soo; Jang, Sung Kyu; Lee, Dong Hyung; Kim, Ki Hyung; Na, Yong Jin; Kim, Jee Yeon; Kim, Hwal Woong; Choi, Kyung Un

Original Article

Korean Journal of Obstetrics & Gynecology 2006;49(7):1463-1470.
Published online July 1, 2006.

MTA1 expression in epithelial ovarian neoplasm.

Man Soo Yoon, Sung Kyu Jang, Dong Hyung Lee, Ki Hyung Kim, Yong Jin Na, Jee Yeon Kim, Hwal Woong Kim, Kyung Un Choi

¹Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Pusan, Korea. msyoon@pusan.ac.kr
²Department of Pathology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

OBJECTIVE
MTA1 has been identified as a metastasis-promiting gene, and its gene expression is correlated with invasion and metastasis in several cancers. We examined MTA1 expression levels in epithelial ovarian neoplasm. METHODS: Expression of MTA1 was evaluated by immunohistochemistry and tissue array in 53 benign tumors, 27 borderline tumors and 68 malignant tumors. The data was analyzed in reference to various clinicopathological parameters. RESULTS: Increased expression of MTA1 was significantly correlated with histologic grade and FIGO stage. There was no relationship between MTA1 expression and age, histologic type, tumor size. CONCLUSION: These results suggest that MTA1 is closely related to invasiveness and progression in epithelial ovarian neoplasm. The MTA1 could thus potentially provide information on the mechanism of cancer invasion and metastasis.

Key Words: MTA1, Immunohistochemistry, Tissue array, Epithelial ovarian neoplasms