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Korean Journal of Obstetrics & Gynecology 2006;49(9):1934-1940.
Published online September 1, 2006.
The role of angiotensin II to regulation of steroidogenic pathway in human ovarian follicle.
Hun Yul Lee, Duck Sung Ko, Hyo Jung Kim, Sun Ok Oh, Won Il Park, Seo Yoo Hong, Jung Hwan Shin, Jin Yong Lee, Byong Hun Cha
1Department of Obstetrics and Gynecology, College of Medicine, Eulji University, Korea. pwi3110@eulji.or.kr
2Eulji Medical Science Institute, Eulji University, Korea.
3Department of Clinical Pathology, Seoul Health College, Korea.
Abstract
OBJECTIVE
The exact mechanism of angiotensin II to steroidogenesis is still speculative in spite of many researches especially in human and these were performed indirectly with serum or follicular fluid. Under the hypothesis that ovarian RAS increases androgen, decreases progesterone synthesis in normal human ovary, we investigated the exact action of angiotnesin II on human ovary. METHODS: After appliance of angiotensin II and saralasin to the normal human ovarian follicles, we measured sex steroids like progesterone, testosterone, DHEA and enzymes like HSD3beta2, CYP 17 to see the action of angiotensin II and its antagonist, saralasin. The results were analyzed by ANOVA test. RESULTS: Angiotensin II increased androgen synthesis but did not affect progesterone synthesis. There were no difference of HSD 3beta2 mRNA expression in angiotensin II and saralasin group compared with control group. The expression of CYP17 mRNA was increased by angiotensin II but did not reach statistically significant level. CONCLUSION: Angiotensin II could increase androgen production probably via overexpression of CYP17, but had no efffect on progesterone production.
Key Words: Human ovary, Angiotensin II, Androgen, Progesterone
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