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Korean Journal of Obstetrics & Gynecology 2006;49(9):1999-2003.
Published online September 1, 2006.
Mixed Large Cell Neuroendocrine Tumor and Adenocarcinoma of the Ovary.
Wonjeong Yoo, Noh Hyun Park, Hoenil Jo, Soo Jin Chae, Hye Sil Seol, In Ae Park, Jae Weon Kim, Yong Sang Song, Soon Beom Kang, Hyo Pyo Lee
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. pnhkhr@snu.ac.kr
2Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea.
Neuroendocrine tumor is a very heterogenous group arising from the neuroendocrine cells. Especially, large cell neuroendocrine tumor of the ovary is a extremely rare aggressive neoplasm, characteristically arising in association with a surface epithelial tumor. This report describes a mixed type of large cell neuroendocrine carcinoma and adenocarcinoma of the ovary. A 63-year old woman presented with abdominal distension and discomfort underwent staging laparotomy under the impression of ovarian cancer. The operation revealed an small ovarian mass with invasion of multiple region in peritoneal cavity by the tumor. Immunohistochemical and ultrastructural analysis confirmed the neuroendocrine nature of the tumor. The adenocarcinoma in this case is mixture of mucinous and endometrioid type. A diagnosis of stage IIIc mixed large cell neuroendocrine tumor and adenocarcinoma of the ovary was rendered. She is subsequently being treated with Paclitaxel and Carboplatin combination chemotherapy.
Key Words: Large cell neuroendocrine tumor, Ovarian adenocarcinoma

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