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Korean Journal of Obstetrics & Gynecology 2006;49(11):2243-2252.
Published online November 1, 2006.
Molecular markers associated with radiation resistance and new molecular agents.
Duk Soo Bae
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ds123.bae@samsung.com
Abstract
Radiation therapy is a key modality in the management of a majority of patients diagnosed with cancer. To know prognostic markers related radiation response can aid in refining our treatment strategies and improving outcomes. With the help of powerful molecular tools, a substantial amount of research efforts have been devoted to identifying molecular markers for prognostic and therapeutic strategies. In this review, we summarize recent research efforts evaluating molecular markers or pathways as they relate to radiation resistance of solid tumors. With respect to radiation response, literatures regarding molecules related to growth factors, apoptosis, cell cycle, angiogenesis, heat shock protein, and histone deacetylase will be reviewed. We also introduce new molecular agents enhancing radiation response which are available in clinic. In addition, we discuss current clinical trials using these molecular agents on cervical cancer.
Key Words: Molecular markers, Radiation sensitivity, Radiation resistance, Cervical cancer, Clinical trials


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