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Korean Journal of Obstetrics & Gynecology 2006;49(11):2326-2334.
Published online November 1, 2006.
Small Cell Carcinoma of the uterine Cervix: Clinicopathologic characteristics and prognostic factors of the 19 cases.
Suk Keun Choe, Min Hyung Jung, Dae Yeon Kim, Dae Sik Seo, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam, Jung Eun Mok
1Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. ymkim@amc.seoul.kr
2Department of Obstetrics and Gynecology, College of Medicine, Kyung Hee University, Seoul, Korea.
Abstract
OBJECTIVE
To analyze the clinicopathologic characteristics, prognostic factors, and survival time of small cell carcinoma of the uterine cervix. METHODS: The medical records of 19 patients who were diagnosed with small cell carcinoma of the uterine cervix and whose initial treatment was between October 1996 and December 2004 were reviewed retrospectively. Clinicopathologic characteristics, FIGO stage (classification according to the International Federation of Gynecology and Obstetrics), tumor size, lymph node metastasis, treatments, and overall survival were analyzed. RESULTS: Mean age at diagnosis was 48.4 years. The overall survival time was 57.3 months, and 5-year survival rate was 52.6%. Twelve patients were in FIGO stage I or IIa and 7 were in FIGO stages IIb-IV. Immunohistochemical analysis showed positive staining for neuroendocrine marker, chromogranin and synaptophysin, in 17 patients, and negative in 2 patients. Tumor size at diagnosis was under 2 cm in 12 patients and over 2 cm in 7 patients. Disease recurred in 8 patients, and 9 patients died. Through analyzing Overall survival time, FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterine cervix. CONCLUSION: Our study found FIGO stage and tumor size were significant prognostic factors in small cell carcinoma of the uterine cervix.
Key Words: Small cell carcinoma, Uterine cervix, Survival rate, Prognostic factors


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