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Korean Journal of Obstetrics & Gynecology 2006;49(11):2362-2370.
Published online November 1, 2006.
Effects of critical time-point for selection of early cleaving 2-cell embryos on the pregnancy outcomes of IVF.
Jong Hoon Park, Dong Soo Suh, Mi Kyoung Kim, Kyu Sup Lee
1Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Korea. kuslee@pusan.ac.kr
2Infertility Clinic, Pusan National University Hospital, Korea.
Abstract
OBJECTIVE
Evaluation of early cleaving time to 2-cell stage has been proposed for the selection of embryos with high implantation potential. In order to provide criteria for the selection of early cleaving 2-cell embryo, a prospective study was performed. METHODS: Embryos that had cleaved early at 25 hours and 27 hours postinsemination were designated as EC (early cleavage)-1 and EC-2, respectively, while others were designated as NEC (non-early cleavage). Statistical analysis was performed using the unpaired student t-test and chi-square test. P<0.05 was considered statistically significan RESULTS: At least one early cleavage embryo was observed in 98 (51.5%) for the EC-1 and 44 (23.2%) for the EC-2 of the 190 cycles assessed. Clinical pregnancy rates were significantly higher in the EC-1 group (58.2%) compared to the EC-2 group (31.8%) or the NEC group (22.9%) (P<0.05). Clinical pregnancy rates and implantation rate were increased if at least one EC-1 embryo was produced, and the increased pregnancy outcome was related positively with the number of EC-1 embryo. When the number of EC-1 embryo transferred was 0 or 1, most pregnancies were singleton (88.0%, 87.5%, respectively). However, when the number of EC-1 embryo transferred was 2 or more, multiple pregnancy rates were increased up to around 40%. CONCLUSION: These results shows that 25 hours postinsemination is more effective than 27 hours as a critical time-point for the selection of early cleaving 2-cell embryos with high implantation potential, and that number of early cleaving embryos is an important parameter for the prediction of pregnancy outcome including the chance of multiple pregnancies.
Key Words: Early cleaving 2-cell embryos, Critical time-point, Pregnancy outcome
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