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Korean Journal of Obstetrics & Gynecology 2007;50(1):93-100.
Published online January 1, 2007.
Association study of 5-HTT gene polymorphism with fear during childbirth.
Min Jeong Kim, Jeong Soo Choi, Jeong Namgung, In Yang Park, Soo Young Hur, Jong Chul Shin, Dae Jin Kim, Byung Rae Park, Hyoung Doo Shin, Sa Jin Kim
1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University, Seoul, Korea. ksajin@catholic.ac.kr
2Department of Psychiatry, College of Medicine, The Catholic University, Seoul, Korea.
3SNP Genetics, Inc, Korea.
The fear and anxiety in the biological processes of childbirth have been of clinical interest, but the studies addressing this subject are rare, particularly where the outcome of the pregnancy has been favourable. In this study, single nucleotide polymorphisms were studied for understanding the fear during childbirth in 534 Korean pregnant women. The frequencies of each SNP were 5-HTT -15375 insdel (44 bp) 0.24, -1002A>C 0.10, -922A>C 0.11, +18784A>C 0.073 in Korean pregnant women (n=534). No polymorphisms was found in 5-HTT +3746G>C The relationship between the fear during childbirth and genetic polymorphisms was investigated by multiple regression analysis adjusting for parity in 293 women who gave birth to a child vaginally and made a reply to Delivery Fear Scale (DFS) which was the measuring instrument for the fear during childbirth among 534 Korean pregnant women. There was no genetic association between the 5-HTT gene polymorphism and fear during childbirth. The results of this study show that the psychological, social, environmental factors play the major role in the fear during childbirth whereas this gene (5-HTT) most likely has only a minor effect in its etiology. And other genes and the interactions between them have been thought to make complex effects. In order to identify the fear during childbirth, further studies will have to be focused on the comprehensive research of the social, psychological, environmental factors and the interaction of the connected genes.
Key Words: Fear, Childbirth, 5-HTT, Genetic polymorphism

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