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Korean Journal of Obstetrics & Gynecology 2007;50(1):207-211.
Published online January 1, 2007.
A case of lymphoepithelioma-like carcinoma of the uterine cervix.
Mi Lyoung Kim, Hang Jo You, Eun Suk Yoon, Sung Hyuk Sim, Bon Sang Koo, Won Duk Joo, Hee Jeong Cha, Hyun Woo Lee
1Department of Obstetrics & Gynecology, Ulsan University Hospital, Ulsan, Korea. dryu0210@naver.com
2Department of Pathology, Ulsan University Hospital, Ulsan, Korea.
Abstract
Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor with 0.7% of all primary cervical malignancies. It may grossly range from no visible cervical lesion to a large exophytic cervical mass and histologically similar neoplasms occur in the nasopharynx. It has been classified as a subtype of squamous cell carcinoma. But, after reviewing the literature, this tumor is a distinct carcinoma of the cervix that differs from squamous cell carcinoma. LELC is composed of undifferentiated cells surrounded by a marked inflammatory infiltrate, characterized by plasma cells and lymphocytes in the stroma. It may represent a better prognostic group than the more common squamous cell carcinoma of the cervix because of lack of lymph node metastasis. Typically affects a younger population of women, is more prevalent in noncaucasian population (especially, those of Asian descent). However, it is not clearly understood, Epstein-Barr virus play in the pathogenesis of cervical LELC while humam papilloma virus (HPV) is a risk factor for squamous cell carcinoma. The prognosis is good only by surgical treatment. Radiation therapy also appears to be effective in eradicating localized, low-stage disease (radiosensitive). The authors have experienced one case of LELC of the uterine cervix. We report a case with a brief review.
Key Words: Lymphoepithelioma-like carcinoma (LELC), Uterine cervix


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