| A case of lymphoepithelioma-like carcinoma of the uterine cervix. |
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Mi Lyoung Kim, Hang Jo You, Eun Suk Yoon, Sung Hyuk Sim, Bon Sang Koo, Won Duk Joo, Hee Jeong Cha, Hyun Woo Lee |
1Department of Obstetrics & Gynecology, Ulsan University Hospital, Ulsan, Korea. dryu0210@naver.com
2Department of Pathology, Ulsan University Hospital, Ulsan, Korea. |
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| Abstract |
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Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor with 0.7% of all primary cervical malignancies. It may grossly range from no visible cervical lesion to a large exophytic cervical mass and histologically similar neoplasms occur in the nasopharynx. It has been classified as a subtype of squamous cell carcinoma. But, after reviewing the literature, this tumor is a distinct carcinoma of the cervix that differs from squamous cell carcinoma. LELC is composed of undifferentiated cells surrounded by a marked inflammatory infiltrate, characterized by plasma cells and lymphocytes in the stroma. It may represent a better prognostic group than the more common squamous cell carcinoma of the cervix because of lack of lymph node metastasis. Typically affects a younger population of women, is more prevalent in noncaucasian population (especially, those of Asian descent). However, it is not clearly understood, Epstein-Barr virus play in the pathogenesis of cervical LELC while humam papilloma virus (HPV) is a risk factor for squamous cell carcinoma. The prognosis is good only by surgical treatment. Radiation therapy also appears to be effective in eradicating localized, low-stage disease (radiosensitive). The authors have experienced one case of LELC of the uterine cervix. We report a case with a brief review. |
| Key Words:
Lymphoepithelioma-like carcinoma (LELC), Uterine cervix |
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