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Korean Journal of Obstetrics & Gynecology 2007;50(6):858-864.
Published online June 1, 2007.
Expression of 14-3-3 proteins and Bax in the placenta of preeclampsia.
Ji Kwon Park, Seon Im Kim, Won Young Paik
1Department of Obstetrics and Gynecology, College of medicine, Gyeongsang National university, JinJu, Korea. wypaik@gnu.ac.kr
2Institute of Health Sciences, College of medicine, Gyeongsang National university, JinJu, Korea.
Abstract
OBJECTIVE
Purpose of our study was to examine the expression level of 14-3-3 proteins and Bcl-2 family and to estimate the interaction between 14-3-3 proteins and Bcl-2 family in normal and preeclamptic placenta. METHODS: Placental tissues were sampled from preeclampsia with caesarean delivery (n=5) and normal pregnant women with caesarean delivery (n=5). Western blot and immunoprecipitation related Western blotting were performed on all placental samples. Unpaired Student t-test was used to determine the statistical significance. RESULTS: Western blot analysis revealed that the expression of Bax and 14-3-3 zeta was significantly greater in the preeclamptic placenta than in the normal placenta. Immunoprecipitation related Western blotting revealed that the interaction between 14-3-3 zeta and Bax was significantly less in the preeclamptic placenta than in the normal placenta. CONCLUSION: Increased expression of Bax and reduced interaction (between) 14-3-3 zeta and Bax in preeclamptic placenta might influence pathogenesis or sequelae of preeclampsia. Further study is needed to identify the trigger that induces dissociation of Bax from 14-3-3 proteins.
Key Words: Preeclampsia, Placenta, 14-3-3 Proteins, Bax Protein


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