The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.

Shin, Su Il; Chong, Hye In; Kim, Jeong Tae; Suh, Dong Soo; Yoon, Man Soo; Choi, Kyung Un; Lee, Chang Hun

Original Article

Korean Journal of Obstetrics & Gynecology 2007;50(8):1100-1106.
Published online August 1, 2007.

The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.

Su Il Shin, Hye In Chong, Jeong Tae Kim, Dong Soo Suh, Man Soo Yoon, Kyung Un Choi, Chang Hun Lee

¹Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@webmail.pusan.ac.kr
²Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.

Abstract

OBJECTIVE
To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer. METHODS: Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining. RESULTS: Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413). CONCLUSION: PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.

Key Words: PARP, Epithelial ovarian cancer