Contemporary clinical trials in uterine corpus malignancies.

Ryu, Hee Sug

Clinical Trial

Korean Journal of Obstetrics & Gynecology 2007;50(10):1299-1307.
Published online October 1, 2007.

Contemporary clinical trials in uterine corpus malignancies.

Hee Sug Ryu

Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea. hsryu@ajou.ac.kr

Abstract

Uterine cancer is the most common gynecologic malignancy in Western countries. In Korea, its incidence has been rising, and the increased incidence is associated with a rising death rate. The first two decades of endometrial cancer study by the GOG began with a prospective, surgicopathologic staging trial that was the cornerstone for development of all subsequent trials. The therapeutic strategies were tailored to disease extent - low risk, intermediate risk, and high risk groups of patients. There were great advances in the area of chemotherapeutic agents through a number of extensive phase II trials. New trials of these agents have been opened for the patients with advanced or recurrent uterine cancers.

Key Words: Endometrial cancer, Uterine sarcoma, Clinical trials