Papillary carcinoma arising in a struma ovarii of the complex teratoma.

Hong, Ran; Lim, Sung Chul; Song, Chang Hun; Kee, Keun Hong; Lee, Mi Ja

Case Report

Korean Journal of Obstetrics & Gynecology 2007;50(11):1552-1557.
Published online November 1, 2007.

Papillary carcinoma arising in a struma ovarii of the complex teratoma.

Ran Hong, Sung Chul Lim, Chang Hun Song, Keun Hong Kee, Mi Ja Lee

¹Department of Pathology, College of Medicine, Chosun University, Gwangju, Korea. sclim@chosun.ac.kr
²Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea.

Abstract

Benign or malignant tumors that arise in a benign cystic teratoma are rare. Malignant transformation in mature cystic teratoma of ovary is reported to occur in 1~3%. Several types of malignancy can occur from any of three germ-cell layers, but the most common malignancy is a squamous cell carcinoma derived from ectoderm. We experienced a papillary carcinoma arising in a struma ovarii of the complex teratoma. 74-year-old female presented with an abdominal discomfort. A pelvic ultrasonograph and computed tomography detected a 7 x 6 cm-sized and well-circumscribed cystic mass at the anterior to the uterus. The inner part of the mass was filled with cystic fluid showing low-density, however, solid portion including fat and soft tissue accompanied by calcification was identified in more than half of the entire tumor volume. The patient underwent a bilateral salpingo-oophorectomy. On histopathologic examination, the lesion was consistent with papillary carcinoma with squamoid features arising in a struma ovarii of the mature cystic teratoma. We herein report a case of the very rare papillary carcinoma arising in a struma ovarii of the complex teratoma and review the available literature.

Key Words: Ovary, Teratoma, Papillary carcinoma, Struma ovarii