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Korean Journal of Obstetrics & Gynecology 2008;51(2):137-146.
Published online February 1, 2008.
Association study of LEP and LEPR gene polymorphisms and the development of type 2 diabetes mellitus in Korean women with a history of gestational diabetes.
Young Joon Park, Se Ryun Kim, Jong Wook Kim, Min Hyeung Kim, Jae Hyug Yang, Hyeong Jin Kim, Youl Hee Cho, Sung Ro Jung
1Department of Obstetrics and Gynecology, Kwandong University College of Medicine, Gangneung, Korea.
2Department of Internal Medicine, Kwandong University College of Medicine, Gangneung, Korea.
3Department of Medical Genetics, Hanyang University College of Medicine, Seoul, Korea.
4Department of Obstetrics and Gynecology, Hanyang University College of Medicine, Seoul, Korea. jungsn@hanyang.ac.kr
Abstract
OBJECTIVE
The history of gestational diabetes (GDM) is a high risk for the development of type 2 diabetes mellitus (T2DM). The purpose of this study is to investigate the genetic association of LEP and LEPR gene polymorphisms and the development of T2DM in Korean women of history of GDM. METHODS: Women diagnosed as GDM during pregnancy from January 1992 to December 2002 were recruited. Those women with a T2DM at the time of study were classified as T2DM positive group, and without T2DM, as T2DM negative group. 2 genes (LEP and LEPR genes) and 8 SNPs (LEP-632G>A, +4950G>A, +4998A>C, and LEPR-141013T>C, -186A>G, +5193G>A, +7187A>C, +27265A>G) were selected. The TaqMan assay for genotyping and the statistical analysis for phenotypic and genetic factors between 2 groups were analyzed. RESULTS: A total of 54 women, T2DM positive (n=20) and T2DM negative (n=34) were enrolled. At the time of diagnosis of GDM, HbA1c, 50 g and 100 g oral glucose tolerance test, and insulin level were significantly associated between T2DM positive and negative groups (P<.05). In analysis of genetic risk to T2DM, the significant association related with any SNPs was not shown between T2DM positive and negative groups. CONCLUSION: In Korean women having past history of GDM, there was no relationship between 2 genes and the development to T2DM. To clarify a effect of candidate genes related with development of T2DM, there will need more samples and genes.
Key Words: Type 2 diabetes mellitus, Gestational diabetes, Leptin gene, Leptin receptor gene, Polymorphism


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