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Korean Journal of Obstetrics & Gynecology 2008;51(3):305-312.
Published online March 1, 2008.
Effectiveness of preemptive Gabapentin on postoperative pain after vaginal hysterectomy.
Hyun Mi Kim, Eun Ok Kim, Ji Eun Song, Sung Ho Park, Hyun Ah Jun, Hongbae Kim, Keun Young Lee
Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Seoul, Korea. drhbkim@hallym.or.kr
Abstract
OBJECTIVE
Gabapentin is a new generation anticonvulsant drug. Preemptive gabapentin may produce analgesic effect in postoperative patient and have antiemetic effect. The aim of the present study was to investigate the opioid-sparing and analgesic effect of preemptive gabapentin on postoperative pain in patient undergoing vaginal hysterectomy. METHODS: In a randomized, double-blind, controlled study, 40 patients scheduled for an elective vaginal total hysterectomy were investigated/-. The patients were randomized to receive either oral gabapentin 1200mg (GABA group 2, n=17) or 900mg (GABA group 1, n=13) with premedication the night before and again 2hours before surgery. The other group (control group, n=10) had only routine premedication without gabapentin. All patients received patient-controlled analgesia (PCA). Postoperatively, pain was assessed using a visual analogue scale (VAS, 0-10) at time 1, 2, 4, 8, and 20 hours. Cumulative PCA consumption and opioid-related adverse events (nausea, vomiting, dizziness) was recorded. RESULTS: There was significant decrease of fentanly consumption in gabapentin group (GABA 2 group : 57.51+/-8.95 mg, GABA 1 group : 52.21+/-5.78 mg) compared to control group (50.63+/-2.55 mg)(p<0.05). There was no significant difference in side-effect (nausea, vomiting, dizziness) were observed between case and control group. CONCLUSIONS: Preemptive gabapentin has a good analgesic effect and reduce postoperative fentanyl consumption on postoperative pain after vaginal hysterectomy. Gabapentin effectively rescue analgesic requirement in post-operative patients with vaginal total hysterectomy.
Key Words: Gabapentin, Opioid-sparing, Postoperative pain


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