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Korean Journal of Obstetrics & Gynecology 2008;51(4):407-412.
Published online April 1, 2008.
The relationship between serum p53 autoantibodies and prognostic relevance of epithelial ovarian cancer.
Jeong Shin Park, Suk Bong Koh
Departments of Obstetrics and Gynecology, School of Medicine, Catholic University of Daegu, Daegu, Korea. sbko@cu.ac.kr
Abstract
OBJECTIVE
The aim of this study was to determine whether a significant in preoperative serum p53 autoantibodies in epithelial ovarian cancer. METHODS: Serum autoantibodies against the p53 protein (p53 AAb) were analysed with a newly developed enzyme-linked immunosorbent assay (ELISA) based on highly purified and renatured p53. In a hospital -based retrospective study, preoperative sera from 17 patients with epithelial ovarian cancer and 15 patients with benign tumors of the ovaries, 15 healthy women were studies. RESULTS: The prevalence of p53 AAb in patients with epithelial ovarian cancer was 35.3% (6/17). No p53 AAb were found in patients with benign tumors and healthy women. Presence of p53 AAb positively correlated with older age, poor response of chemotherapy. But the differences in the tumor stage, grade, poor progression free survival rate were not statistically significant. CONCLUSIONS: The assessment of preoperative serum p53 AAb seems to have a limited clinical value in the epithelial ovarian cancer.
Key Words: Serum p53 autoantibody, Epithelial ovarian cancer


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