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Korean Journal of Obstetrics & Gynecology 2008;51(9):957-964.
Published online September 1, 2008.
Heat Shock Protein 60 and 27 expressions on the trophoblast of preterm birth.
Suk Young Kim, Eun Joo Chung, Hyun Myong Oh, Jung Min Kim, Deul Lae Min, You Jin Hwang
1Department of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science. Incheon, Korea. ksyob@gilhospital.com
2Division of Biological Science, Graduate School of Medicine, Gachon University of Medicine and Science. Incheon, Korea.
Abstract
OBJECTIVE
To compare the distribution and expression of hsp60 and hsp27 in placental trophoblast between preterm and term placenta and to observe hsp immune response in relation to the pathogenesis of preterm birth. METHODS: 22 cases of preterm trophoblast, between 24 weeks and 36 weeks gestation, which were developed spontaneous onset or less than 24 hours after rupture of membrane were obtained. And aged-matched, 22 cases of normal term trophoblast, as control were also obtained after informed consent from each patient. The protein extraction form trophoblast was stained by immunohistochemical methods and was measured by the assay of Western blots. And the density of band using Image-writer were taken and statistical assay were performed as significance <0.05. RESULTS: The expressions of hsp60 and hsp27 in trophoblast of preterm and term placenta were identified by immunohistochemical staining method. The hsp60 had significantly higher expression in trophoblast of preterm birth than in that of term birth (P<0.001) and the hsp27 also had significantly higher expression in trophoblast of preterm birth than in that of term birth (P<0.02) CONCLUSION: The higher expression of hsp60 and hsp27 in trophoblast of preterm birth might be suggested the development of immune response to occur preterm labor Further study are necessary to determine the exact actions of hsp60 and27 in trophoblast and to understand the immune mechanism of preterm birth.
Key Words: Preterm birth, Heat shock protein (hsp), Trophoblast


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