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Korean Journal of Obstetrics & Gynecology 2008;51(9):974-981.
Published online September 1, 2008.
Expression of Wnt 1 and beta-catenin in epithelial ovarian cancer.
Kyoung Ran Yim, Chan Lee, Yong Min Kim, Kwang Il Kim, Seung Jo Kim, Youn Yeung Hwang, Seon Yeong Lee, Young Jeong Na, Sang Geun Jeong, Yoe Un Oh
1Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, Korea. ew97flora@hanmail.net
2Department of Pathology, College of Medicine, Pochon CHA University, Seongnam, Korea.
Abstract
OBJECTIVE
We were trying to identify the expression of Wnt 1 and beta-catenin in normal ovarian epithelium and epithelial ovarian tumor. METHODS: We used archival formalin-fixed and paraffin-embedded tissues from Comprehensive Gynecologic Cancer Center and the Department of Pathology at Bundang CHA Hospital from 2000 to 2005. Immunohistochemical staining for Wnt 1 and beta-catenin was performed on the ovarian epithelial tissues. Statistical analyses were performed with SPSS 10.1 for Windows and significance was defined as P<0.05. RESULTS: Of 114 cases, the cases were composed of 54 carcinomas, 40 borderline tumors, 12 benign tumors and 8 normal control ovarian tissues. Abnormal nucleocytoplasmic expression of beta-catenin was found in 4 endometrioid carcinomas. The nuclear expression of beta-catenin was found especially in the components of the endometrioid carcinoma (28.6%, P<0.05). Wnt 1 was overexpressed in all 9 clear cell carcinomas, but not frequent in the other types of malignant tumors (P<0.05). We found a statistically significant correlation between beta-catenin nuclear localization and endometrioid carcinomas. And we found a significant correlation between Wnt 1 expression and clear cell carcinomas. CONCLUSION: It does not seem that Wnt 1 over expression directly provoke the nuclear localization of beta-catenin. But, deregulation of beta-catenin and Wnt 1 may play a role in the pathogenesis of ovarian epithelial carcinogenesis of endometriod carcinoma and clear cell carcinoma. Evaluating this avenue of regulation of beta-catenin and Wnt protein in ovarian epithelial carcinoma may provide a new direction for early diagnosis and treatment in ovarian epithelial carcinoma and provide opportunities for making a certain biomarkers.
Key Words: Epithelial ovarian carcinoma, Wnt 1, beta-catenin, Immunohistochemical staining


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