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Korean Journal of Obstetrics & Gynecology 2008;51(9):1030-1033.
Published online September 1, 2008.
Gestational trophoblastic disease in a patient with twin pregnancy consisting of complete hydatidiform mole and co-existing live fetus after in vitro fertilization.
Ari Kim, Ji Eun Han, Hyun Young Ahn, Seok Nyun Bae, Jong Chul Shin
1Department of Obstetrics and Gynecology, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea. jcshin@catholic.ac.kr
2Fertility Center of CHA General Hospital, college of Medicine, Pochon CHA University, Seoul, Korea.
A 45-year-old, multigravida woman who had been pregnant with dichorionic twins after in vitro fertilization (IVF) was referred due to early onset of severe preeclampsia. Ultrasonographic findings were multicystic tumor and normal placenta with a live fetus appropriate for 14 weeks of gestation. After therapeutic abortion, the multicystic tumor showed hydropic feature. The fetus had no anomalous finding. Histopathologic analysis revealed complete hydatidiform mole and normal placental tissue attaching three vesseled umbilical cord. Gestational trophoblastic disease (GTD) was diagnosed due to rising levels of serial beta-hCG values and abnormal sonographic findings. The patient treated with combined chemotherapy. We report a case of a complete hydatidiform mole and coexisting normal live fetus after IVF, which was complicated with early onset severe preeclampsia and persistent GTD.
Key Words: Gestational trophoblastic neoplasms, Twins, Hydatidiform mole, Fertilization in vitro

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