Korean J Obstet Gynecol Search

CLOSE


Korean Journal of Obstetrics & Gynecology 2008;51(10):1103-1111.
Published online October 1, 2008.
Folic acid and vitamin B12 intake in relation to risk of endometrial cancer: Case-control study.
Kyung Hee Lee, Jae Kwan Lee, Jae Hoon Kim, Jong Min Lee, Eun Seop Song, Mi Kyung Kim
1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. jklee38@korea.ac.kr
2Department of Obstetrics and Gynecology, Women's Cancer Clinic, Yonsei University College of Medicine, Seoul, Korea.
3Department of Obstetrics and Gynecology, Kyunghee University College of Medicine, Seoul, Korea.
4Department of Obstetrics and Gynecology, College of Medicine, Inha University, Incheon, Korea.
5Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Goyang, Korea.
Abstract
OBJECTIVE
To evaluate the role of folic acid and vitamin B12 in the etiology of endometrial cancer, we performed a case-control study comparing oral intakes of folic acid, vitamin B12 and serum levels of folate and vitamin B12 in 48 endometrial cancer patients and 563 controls. METHODS: From August 2005 to August 2006, 48 histologically diagnosed endometrial cancer patients and 563 controls were enrolled in the study. Informations about dietary intake of folic acid, vitamin B12 were obtained by semi-quantitative food frequency questionnaire (SQFFQ) and serum levels of folate and vitamin B12 were measured. Odds ratios (OR) and 95% confidence intervals (CI) were assessed with logistic regression and adjusted for energy, age, smoking status, alcohol consumption status, BMI, menopause, oral contraceptive use. RESULTS: Endometrial cancer risk was not significantly associated with intakes of folic acid and vitamin B12. After assessing tertile subgroup levels of folic acid intake, multivariate OR of 2nd tertile subgroup was 0.71 (95% CI: 0.36~1.6) and multivariate OR of 3rd tertile subgroup was 0.92 (95% CI: 0.45~1.9). And according to tertile subgroup levels of vitamin B12 intake, multivariate OR of 2nd tertile subgroup was 1.17 (95% CI: 0.57~2.39) and multivariate OR of 3rd tertile subgroup was 0.94 (95% CI: 0.43~2.05). However, serum folate and vitamin B12 levels were significantly associated with a reduction of endometrial cancer risk as a result of multivariate OR 0.42 (95% CI: 0.22~0.78) and 0.32 (95% CI: 0.15~0.68) by logistic regression. CONCLUSIONS: This study suggests that dietary intakes of folic acid and vitamin B12 are not significantly related to the risk of endometrial cancer. But we could confirm reduction of endometrial cancer risk in higher serum folate and higher serum vitamin B12 subgroup.
Key Words: Folic acid, Vitamin B12, Endometrial cancer
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 379 View
  • 0 Download
Related articles in Obstet Gynecol Sci

Dietary pattern and risk of endometrioma in Korean women: a case-control study2021 January;64(1)



ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
POLICY
FOR CONTRIBUTORS
Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2021 by Korean Society of Obstetrics and Gynecology.

Developed in M2PI

Close layer
prev next