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Korean Journal of Obstetrics & Gynecology 2008;51(11):1288-1294.
Published online November 1, 2008.
The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas.
Chang Min Park, Song Yee Han, Insun Kim, Hyun Chul Kim, Jae Seong Kang
1Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea. jskang@kumc.or.kr
2Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
Abstract
OBJECTIVE
The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters. METHODS: One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity. RESULTS: Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients. CONCLUSIONS: Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.
Key Words: Ki-67 antigen, Immunohistochemistry, Ovary, Carcinoma


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