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Korean Journal of Obstetrics & Gynecology 2009;52(1):68-74.
Published online January 1, 2009.
Ultrasound-guided local injection of potassium chloride (KCl) and methotrexate (MTX) in the treatment of cornual pregnancy.
Hea Ree Park, Myoung Jin Moon, Seung Joo Shin, Sung Woon Jang, Eun Hee Ahn, Sang Hee Jung, Sung Shin Shim, Suk Ho Kang, Hyun Chul Kim, Youn Yeung Hwang, Min Jung Baek
Department of Obstetrics and Gynecology, Pochon University, Bundang Cha Women's Hospital, Bundang, Korea. mmj33@hanmail.net
To evaluate efficacy and safety of local injection of potassium chloride (KCl) and methotrexate (MTX) in the treatment of cornual pregnancy. METHODS: We retrospectively reviewed all cases of cornual pregnancy treated conservatively from 2005 through August 2007. Eight cases were identified and two cases were heterotopic interstitial pregnancy. All cases were managed with local injection of KCl or methotrexate under ultrasound guidance and 2 cases were treated with intra-muscular injection of MTX in combination. After the procedure all cases with cardiac activity was confirmed to be aborted by ultrasound. Also serial follow-up sonographic examination and serum beta-hCG measurement were performed. RESULTS: The mean initial beta-hCG level was 53,331.6 mIU/mL and ranged from 14,332 mIU/mL to 125,721 mIU/mL. Mean gestational age was 48.3 days from 40 to 65 days. All cases were aborted successfully and follow up beta-hCG were declined abruptly. Two cases of heterotopic pregnancy resulted in successful deliveries at full term. CONCLUSION: Cornual resection or hysterectomy should no longer be the first line of treatment for hemodynamically stable patients with cornual pregnancy. They can be successfully treated through local injection of MTX or KCl by ultrasound guidance.
Key Words: Cornual pregnancy, Heterotopic pregnancy, Ultrasound guidance, Local injection

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