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Korean Journal of Obstetrics & Gynecology 2009;52(2):228-236.
Published online February 1, 2009.
The clinicopathological relationship of E2F-1 and Ki-67 expression in endometrial cancer.
Hye In Chong, Yun Ji Baek, Ho Jin Jang, Dong Soo Suh, Man Soo Yoon, Kyung Un Choi
1Department of Obstetrics & Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@pusan.ac.kr
2Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.
Abstract
OBJECTIVE
The aim of this study was to evaluate the correlation of E2F-1 and Ki-67 expression with clinicopathological prognostic factors. METHODS: Retrospectively, endometrial cancer slide samples (n=71) were analyzed. E2F-1 and Ki-67 were evaluated using immunohistochemical staining. And as a control (n=21), endometrial tissues were obtained by hysterectomy with benign gynecologic disease. RESULTS: Of 71 cases, the positive E2F-1 expression was 53.5% (38/71) in endometrial cancer. The expression of E2F-1 showed a remarkable positive correlation with myometrial invasion (P=0.001) and lymphovascular invasion (P=0.000). The Ki-67 labeling index was 30.56+/-25.67 in endometrial cancer and 9.38+/-8.35 in normal endometrial tissues (P=0.001). The Ki-67 labeling index showed positive correlations with increased tumor size (P=0.046, gamma=0.238), positive lymph node metastasis (P=0.001, gamma=0.396), cervical invasion (P=0.000, gamma=0.404) and lymphovascular tumor invasion (P=0.000, gamma=0.597). There was a positive correlation between E2F-1 and Ki-67 expression (P=0.000, gamma=0.734). CONCLUSION: The Ki-67 expression seems to be related with tumor invasiveness and growth in endometrial cancer and shows a remarkable positive correlation with E2F-1. The E2F-1 expression seems to be not related as a direct prognostic factor but related with tumor invasiveness and growth in endometrial cancer.
Key Words: Endometrial cancer, E2F-1, Ki-67


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