Clinicopathologic study of ovarian granulosa cell tumors.

Lee, In ho; Kwon, Yong Soon; Hahn, Ho Suap; Yoon, Seok Geun; Hong, Jae Shik; Kim, Tae Jin; Lee, Ki Heon; Shim, Jae Uk; Mok, Jung Eun; Lim, Kyung Taek

Search: Korean J Obstet Gynecol Search

CLOSE

Original Article

Korean Journal of Obstetrics & Gynecology 2009;52(4):429-436.
Published online April 1, 2009.

Clinicopathologic study of ovarian granulosa cell tumors.

In ho Lee, Yong Soon Kwon, Ho Suap Hahn, Seok Geun Yoon, Jae Shik Hong, Tae Jin Kim, Ki Heon Lee, Jae Uk Shim, Jung Eun Mok, Kyung Taek Lim

Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea. mbg215@godpeople.com

Abstract

OBJECTIVE
The aim of this study was to evaluate the clinicopathologic characteristics of granulosa cell tumor of the ovary (OGCT). METHODS: We retrospectively reviewed the medical records of 27 patients with OGCT at our hospitals from January 1995 to December 2003. RESULTS: The mean age was 48.3 years (24~70) and mean follow up period was 56.7 months (12~102). The most common symptom was vaginal bleeding (n=11, 40.7%). The tumors were ranging from 3 cm to 21 cm in diameter (mean: 9.9). Post-surgical FIGO stage was stage I in 20 (74.1%), stage II in 6 (22.2%), and stage III in 1 (3.7%). Endoemetrial samples were available in 21 patients and the results were endometrial carcinoma in 1 and endometrial hyperplasias in 5. Staging operation was performed in 17, unilateral salpingo-oophorectomy in 6, total hysterectomy and bilateral salpingo-oophorectomy in 2, and fertility sparing operation in 2. Postoperative chemotherapy was administered in 13 patients (48.2%). Two patients had recurred and recurrence rate was 7.4% (2/27). Two recurred patients finally died of the disease at 42 months and 103 months after first operation respectively. During follow-up period, 2 patients had 3 pregnancies and all of them delivered at term. CONCLUSION: These results shows that most OGCT is detected in early stage and have relatively excellent survival. However, because OGCT is a slow-growing tumor and has a late recurrence, long time follow-up is required.

Key Words: Granulosa cell tumor, Ovary, Clinical study

TOOLS

Full text via DOI
Download Citation

Share :

METRICS

860 View
10 Download

Related articles in Obstet Gynecol Sci

Clinicopathologic study and ultrasonographic finding of pelvic mass.1991 January;34(1)

Clinicopathological studies on ovarian tumors.1991 January;34(1)

Clinical study on cesarean hysterectomy.1991 February;34(2)

The clinico-pathological study of the torsions of the uterine adnexa .1991 April;34(4)

Clinico-pathologic study and prognosis on malignant germ cell tumor.1991 December;34(12)

ABOUT

ARTICLE & TOPICS

Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES

POLICY

FOR CONTRIBUTORS

Editorial Office: 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea.
Tel: +82-2-2266-7238 Fax: +82-2-3445-2440 E-mail: journal@ogscience.org