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Korean Journal of Obstetrics & Gynecology 2009;52(7):691-699.
Published online July 1, 2009.
Ovulation induction: an up-to-date knowledge.
Sang Don Kim, Byung Chul Jee
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. blasto@snubh.org
Ovulation induction is to make ovulation occur in a woman with ovulatory problems by giving her medical or surgical treatment. The method of ovulation induction varies depends on the cause and classification. In group I of WHO classification, gonadotropins should be used, and in group V or VI which shows hyperprolactinemia, dopamine agonist such as bromocriptine can be used to lower the serum level of prolactin. Group III is not an indication of ovulation induction and ovum donation should be recommended. In group II which is clinically most common, the first choice of treatment is clomiphene. If the initial treatment doesn't work, glucocorticoids, insulin sensitizers such as metformin, or gonadotropins can be added to induce ovulation. Aromatase inhibitor or gonadotropin alone can be an alternative treatment. In patients with polycystic ovary syndrome, ovarian electrocautery, diathermy or laser vaporization can be helpful. In patients with prolactinoma, transsphenoidal pituitary adenomectomy is available.
Key Words: Ovulation induction, Anovulation, Clomiphene, Letrozole
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