Fertility-sparing radical abdominal trachelectomy for cervical clear cell adenocarcinoma unrelated to diethylstilbestrol exposure : A case report.

Kwack, Hyun Sung; Mun, Young Joo; Ha, Jae Eun; Hwang, Sun Jung; Kim, Su Mi; Han, Ku Taek; Ryu, Ki Sung

Obstet Gynecol Sci > Volume 52(9); 2009 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2009;52(9):960-965.
Published online September 1, 2009.

Fertility-sparing radical abdominal trachelectomy for cervical clear cell adenocarcinoma unrelated to diethylstilbestrol exposure : A case report.

Hyun Sung Kwack, Young Joo Mun, Jae Eun Ha, Sun Jung Hwang, Su Mi Kim, Ku Taek Han, Ki Sung Ryu

Division of Gynecologic Oncology. Department of Obstetrics and Gynecology, Catholic University of Korea, Seoul, Korea. ryuks@catholic.ac.kr

Abstract

Clear cell adenocarcinoma (CCAC) is a rare cancer that comprises less than 9% of the cervical adenocarcinoma cases. We experienced a case of fertility-sparing radical abdominal trachelectomy for cervical clear cell adenocarcinoma (CCAC). Thus, reported it. A 27 year old female was diagnosed with clinical stage Ib cervical CCAC. She had no history of maternal exposure to diethylstilbestrol and had negative PAP cytology and HPV tests. She was treated with neoadjuvant chemotherapy followed by radical abdominal trachelectomy. After 2 cycles of postoperative adjuvant chemotherapy, the lesion disappeared completely in an imaging study, and potential fertility was preserved. Radical abdominal trachelectomy with chemotherapy may be a valuable approach for treating stage Ib cervical CCAC in women that wish to preserve potential fertility.

Key Words: Clear cell adenocarcinoma, Cervical cancer, Radical abdominal trachelectomy, diethylstilbestrol