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Korean Journal of Obstetrics & Gynecology 2009;52(9):966-969.
Published online September 1, 2009.
Primary nasal type NK/T cell lymphoma of the endometrium : A case report.
Sung Hak Lee, Hee Joong Lee, Ha Kyun Chang, Tae Chul Park, Ok Ran Shin, Kyo Young Lee
1Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea. shinor@catholic.ac.kr
2Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.
Abstract
Non-Hodgkin lymphoma can involve the female genital tract usually as a manifestation of systemic disease, the vast majority of cases being B cell lineage. We report here one case of nasal type NK/T cell lymphoma arising in the uterus, of a 45-year-old Korean woman. The endometrium and myometrium showed diffuse infiltrative mass with hemorrhage and necrosis. Microscopic examination of the tumor revealed medium-sized atypical lymphoid cells. The tumor cells were positive for cytoplasmic CD3 and CD56, and were negative for vimentin, CD10, smooth muscle actin and desmin. Furthermore, In situ hybridization analysis for Epstein-Barr virus (EBV) RNA was positive. The histopathologic and immunohistochemical findings were consistent with extranodal nasal type NK/T cell lymphoma. We report this case to illustrate that NK/T cell lymphomas can involve, and rarely arise in, the gynecologic tract.
Key Words: Lymphoma, Extranodal NK-T-Cell, Uterus


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