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Korean Journal of Obstetrics & Gynecology 2009;52(11):1144-1151.
Published online November 1, 2009.
The expression of endothelial nitric oxide synthase in the uterus.
Hyoung Jin Sou, Jong Wook Kim, Se Ryun Kim, Sang Yeop Yi
1Department of Obstetrics and Gynecology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea. capis01@paran.com
2Department of Pathology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.
Abstract
OBJECTIVE
Nitric oxide has a short half-life and is easily oxidized by nitrite, we can indirectly find out its activity by measuring the nitric oxide synthase in cells. The purpose of this study is to confirm the differences in the expression modes of eNOS in uterine endometrium and myometrium between the patients of uterine leiomyoma and the control group. METHODS: We defined the patient group as perimenopausal women who were diagnosed with uterine leiomyoma and underwent total hysterectomy, and the control group as the women who had no lesions in uterus. All of them were classified into proliferative phase and secretory phase by the Noyes standards and compared by immunohistochemical stain for eNOS. RESULTS: There is no significant differences between the patients of uterine leiomyoma and the control group statistically (endometrium P=0.319, myometrium P=0.264). The expression of eNOS in the vascular endothelial cells of the endometrium did not show significant differences statistically by menstrual cycle (proliferative phage P=0.549, secretory phage P=0.240). The expression of eNOS in the myometrium also did not show significant differences by menstrual cycle or by group statistically (proliferative phage P=0.279, secretory phage P=0.224). CONCLUSIONS: In this study, the expression of endothelial nitric oxide synthase was higher in the patients of uterine leiomyoma than in the control group, and during the secretory phase in menstrual period, but there was no statistical significance. We suppose that we can get statistically significant results if we have many cases of subjects.
Key Words: Endothelial nitric oxide synthase, Leiomyoma, Uterus, Menstrual cycle


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