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Obstet Gynecol Sci > Volume 53(9); 2010 > Article
Korean Journal of Obstetrics & Gynecology 2010;53(9):804-815.
DOI: https://doi.org/10.5468/kjog.2010.53.9.804    Published online September 1, 2010.
The expression of clusterin, bax, p53, Ki-67, and apoptotic index in epithelial ovarian tumors.
Ji Young Lee, Jung Yeol Na, In Sun Kim, Moon Hyang Park, Jae Seong Kang
1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. jskang@kumc.or.kr
2Department of Pathology, Korea University College of Medicine, Seoul, Korea.
3Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
The purpose of this study was (1) to evaluate the expressions of clusterin, bax, Ki-67, p53, and apoptotic index in epithelial ovarian tumors, borderline and malignant ovarian tumors, (2) to find out the correlation between their expressions and clinicopathological parameters, and (3) to evaluate the effect on the patient's survival according to their expressions. METHODS: The histological and clinical findings of 22 cases of ovarian cystadenomas, 44 cases of borderline tumors and 96 cases of carcinomas were evaluated. Expressions of clusterin, bax, Ki-67, p53, and apoptotic index were studied on paraffin-embedded tissue sections by immunohistochemical methods. RESULTS: The expressions of clusterin, p53, and Ki-67 were higher in ovarian carcinomas than borderline tumors. The overexpression of p53, and Ki-67 were frequent in high stage, poorly differentiated and bilateral ovarian carcinomas. The overexpressions of clusterin, bax, p53, and Ki-67 showed a statistically significant correlation with histologic type. Apoptotic index was higher in bax overexpression group, but there was no correlation with overexpression of clusterin or p53. Ki-67 was higher in p53 overexpression group, but there was no correlation with overexpression of clusterin or p53. There was no statistically significant correlation with each other between the overexpressions of clusterin, bax, p53, and Ki-67. The overexpressions of clusterin, Ki-67, p53 was associated with overall patient's survival in borderline significance. CONCLUSION: The overexpression of p53, and Ki-67 were frequent in poorly differentiated ovarian carcinomas. So the overexpression of p53, and Ki-67 can be used as prognostic factor. The overexpression of clusterin was more in epithelial ovarian carcinomas than in borderline tumors but showed no significant correlation with the overall patient's survival. Further studies are required to clarify the possibility of using clusterin for target therapy in epithelial ovarian carcinomas.
Key Words: Epithelial ovarian tumors, Clusterin, Bax, Ki-67, p53


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