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Obstet Gynecol Sci > Volume 53(11); 2010 > Article
Korean Journal of Obstetrics & Gynecology 2010;53(11):967-972.
DOI: https://doi.org/10.5468/kjog.2010.53.11.967    Published online November 1, 2010.
Evaluation of the usefulness of the fetal femur length and humeral length to detect Down syndrome in Korean subjects.
Hyun Jin Cho, Hye Sung Won, Jae Yun Sim, Pil Ryang Lee, Ahm Kim
1Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
2Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hswon@amc.seoul.kr
Abstract
OBJECTIVE
We investigated the usefulness of shortening of the fetal femur length (FL) and humeral length (HL) to predict Down syndrome at the middle gestation of pregnancy in Korean subjects. METHODS: This retrospective study involved 41 fetuses with Down syndrome and 328 fetuses with normal chromosome between 14+0 and 28+6 weeks of gestation. The expected FL and HL for any biparietal diameter (BPD) was calculated based on the control group data. The odds ratios for measure to expected FL and HL in comparison between normal fetuses and Down syndrome fetuses were calculated. The sensitivities of short FL and HL to predict Down syndrome were analyzed at a fixed false positive rate of 5%. RESULTS: The lengths of femur and humerus long bone for any BPD in Down syndrome group were significantly shorter than the lengths in control group (P<0.001). A low ratio of measured to expected FL and HL increased the risk of fetal Down syndrome (P<0.001). At a fixed false positive rate of 5%, the sensitivities were 21.3% (95% confidence interval [CI] 0.698~0.852, P<0.001) in FL and 29.9% (95% CI 0.773~0.914, P<0.001) in HL. CONCLUSION: Both of short FL and HL are poor marker for Down syndrome at the middle gestation of pregnancy in Korean population though the sensitivity of HL was higher than FL.
Key Words: Down syndrome, Femur length, Humeral length, Prenatal diagnosis, Ultrasound


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