Outcomes after bleomycin, etoposide and cisplatin combination chemotherapy in patients with ovarian yolk sac tumor. |
Ji Young Kim, Yu Jung Shin, Jei Won Moon, Jeong Yeol Park, Dae Yeon Kim, Joo Hak Lee, Jong Hyeok Kim, Yong Man Kim, Young Tak Kim, Joo Hyun Nam |
1Department of Obsterics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. catgut1-0@hanmail.net 2Department of Western Medicine, Life University School of Oriental Medicine, Gardena, USA. |
|
Abstract |
OBJECTIVE The aim of this study was to evaluate the oncologic and reproductive outcomes of patients with ovarian yolk sac tumor after bleomycin, etoposide, cisplatin (BEP) chemotherapy following surgery. METHODS: Of 145 patients with histologically confirmed malignant ovarian germ cell tumor, 43 had yolk sac tumor and received BEP chemotherapy after surgery. A retrospective analysis of these patients was performed. RESULTS: The mean age of 43 patients was 24.8 years (range, 7 to 59 years). Thirty eight patients were nulliparous. Of 179 BEP chemotherapy cycles, grade 1~2 hematologic and non-hematologic adverse events occurred in 46 cycles in 21 patients. Thirty nine patients showed complete remission, 1 patient showed partial remission, and 3 patient had progressive disease during BEP chemotherapy. After median follow-up time of 57 months (range, 3 to 153 months), 5 patients had recurrent disease and three of them died of disease. The 5-year recurrence free survival rate and overall survival rate were 86% and 94%, respectively. After chemotherapy, all but one premenarchal patients had normal menstruation. Of them 5 patients tried to conceive and 3 of them succeeded in pregnancy. CONCLUSION: BEP chemotherapy was very safe and effective in patients with ovarian yolk sac tumor. Survival outcomes are excellent and reproductive outcomes are promising after BEP chemotherapy. |
Key Words:
Malignant ovarian germ cell tumor, Yolk sac tumor, Bleomycin, Etoposide, Cisplatin |
|