Intravenous Immunoglobulin Treatment in Women with Unexplained Recurrent Spontaneous Abortion.

Shin, Myung Shin; Kim, Nak Yon; Kim, Chung Hoon; Kang, Byung Moon; Chang, Yoon Seok; Mok, Jung Eun

Original Article

Korean Journal of Obstetrics & Gynecology 1997;40(4):740-746.
Published online January 1, 2001.

Intravenous Immunoglobulin Treatment in Women with Unexplained Recurrent Spontaneous Abortion.

Myung Shin Shin, Nak Yon Kim, Chung Hoon Kim, Byung Moon Kang, Yoon Seok Chang, Jung Eun Mok

Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.

Abstract

This study was undertaken to verify a specific effect of intravenous immunoglobulin treatment on the outcome of pregnancy in the patients with a history of unexplained recurrent spontaneous abortion. Five patients with a history of unexplained recurrent spontaneous abortion were treated with intravenous immunoglobulin during their following pregnancy, as soon as pregnancy was confirmed. When pregnancy was confirmed, women were started with 10 gm of immunoglobulin intravenously which was repeated every 2 weeks and four to six times. One of them experienced termination of pregnancy due to blighted ovum syndrome at 9th weeks of gestation and four patients delivered live births at term. Two of them had experienced cesarean section because of breech presentation and placenta previa respectively, rest of them delivered vaginally without problem. There were no adverse reaction in the study patients. These results imply that intravenous immunoglobulin could be effective on the patients with a history of unexplained recurrent spontaneous abortion, and could be applied to them as an alternative method of allogenic leukocyte transfusion.

Key Words: Unexplained recurrent spontaneous abortion, Intravenous immunoglobulin