Two Cases of Sertoli-Leydig Cell Tumor without Masculinized Symptom.

Shin, Chang Yeal; Ha, Byeoung Uk; Kim, Heung Ro; Kim, Pyoung Kuk; Kim, Jeoung Wook; Lee, Kang Kook

Case Report

Korean Journal of Obstetrics & Gynecology 1997;40(9):2087-2091.
Published online January 1, 2001.

Two Cases of Sertoli-Leydig Cell Tumor without Masculinized Symptom.

Chang Yeal Shin, Byeoung Uk Ha, Heung Ro Kim, Pyoung Kuk Kim, Jeoung Wook Kim, Kang Kook Lee

Department of Obstetrics and Gynecology, Wallace Memorial Baptist Hospital, Pusan, Korea.

Abstract

Sertoli-Leydig cell tumor is an uncommon tumor that may manifest itself by a characteri-stic virilization symptom. It is a rare gonadal tumor of sex-cord type, representing only 0.1~0.5% of all primary ovarian neoplasm. These tumors are the most common virilizing tumors in women of reproductive age. However, only one-third of patients develop masculinization. We have seen two cases of Sertoli-Leydig cell tumors without the virilizing symptom. These two cases have been confirmed by permanent tissue biopsies and have been presented in a 32-year old female who has had only amenorrhea and in a 56-year old postmenopausal female who has not manifested virilizing symptom. These cases are presented with brief review of the literature.

Key Words: Sertoli-Leydig cell tumors, alpha-fetoprotein, Testosterone