| A Relationship Between Polymorphism of Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women of Korea. |
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J Y Lee, H W Chung, H R Kim, J J Ahn, H K Yoo |
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| Abstract |
OBJECTIVE
The goal of this study was to determine the relationship between BMD and polymorphism of vitamine D receptor gene. METHOD: We amplified exon 2 of VDR and its digestion pattern of Fok I was examined from the 89 women who visited menopause clinic of Ewha Woman`s university. The genetic subtype was classified by its digestion patterns, e.g., FF, Ff, and ff. Bone mineral density of each genetic subtype before and after hormone replacement therapy[HRT] were compared. RESULTS: The genotype distribution was as follows :FF genotype, 35[39%] women; :Ff genotype, 37[41%] women; ff genotype, 17[19%] women. Bone mineral density[BMD] of lumbar spine in subtype FF, Ff, ff was 1.099+/-0.249g/cm2, 1.001+/-0.163g/cm2, 0.998+/-0.157g/cm2, respectively. BMD of femoral neck was 0.897+/-0.177g/cm2, 0.837+/-0.142g/cm2, 0.836+/-0.174g/cm2. There was no statistical significance between the BMD in these groups. However, we could show that BMD in ff group was lower than those in the other groups. In 48 patients out of 89, BMD of lumbar spine after 6 months HRT were elevated by 0.24 SD, 0.17 SD, 0.01 SD in subtype FF, Ff, and ff respectively. Which were not significantly different. [p > 0.05]. CONCLUSION: Vitamin D receptor[VDR] genotype of menopausal women will be used as a predictor of osteoporosis and a good treatment result will be respected by the hormonal treatment for the osteoporosis of FF genotype. |
| Key Words:
Vitamin D receptor, Polymorphism, Bone mineral density |
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