Conservative Treatment of Cervical Pregnancy with MTX Followed by Therapeutic Curettage.

Kang, E J; Kim, H J; Kim, M H; Cho, E N; Kim, H J

Search: Korean J Obstet Gynecol Search

CLOSE

Original Article

Korean Journal of Obstetrics & Gynecology 2001;44(8):1483-1487.
Published online August 1, 2001.

Conservative Treatment of Cervical Pregnancy with MTX Followed by Therapeutic Curettage.

E J Kang, H J Kim, M H Kim, E N Cho, H J Kim

Department of Obstetrics and Gynecology, Ilsin Christian Hospital, Pusan, Korea.

Abstract

OBJECTIVE
To evaluate the safety and efficacy of intramuscular methotrexate injection followed by dilatation and curettage (D & C) for the treatment of ectopic cervical pregnancy. METHOD: Nine patients with cervical pregnancy were treated alternately with four doses of intramuscular methotrexate (1.0 mg/kg) and four doses of intramuscular folinic acid (0.1 mg/kg). On the seventh day after treatment, patients were measured for level of serum beta-hCG (human chorionic gonadotropin) and underwent ultrasounds. According to the result, additional dose of MTX or curettage were done. Serum beta-hCG and ultrasound were checked every week until the level of serum beta-hCG and the finding of ultrasound had been normalized. RESULTS: Eight patients showed normal level in serum beta-hCG and normal finding in ultrasound after the methotrexate/folinic acid therapy followed by D & C. One of nine patients showed increase by double concentrations in serum beta-hCG after the MTX/Folinic acid treatment. After intraamnionic injection of MTX, serum beta-hCG titer was decreased in this case. One week later, D & C was performed. No patient was experienced severe complications. All patients who had wanted a subsequent pregnancy were conceived. CONCLUSION: These results suggest that methotrexate/folinic acid therapy followed by D & C is safe and effective as a primary therapy for ectopic cervical pregnancy.

Key Words: Cervical pregnancy, Methotrexate, Dilatation & Curettage

TOOLS

Full text via DOI
Download Citation

Share :

METRICS

689 View
10 Download

Related articles in Obstet Gynecol Sci

A case of successful treatment of cervical pregnancy with methotrexate.1992 March;35(3)

Treatment of cervical pregnancy with methotrexate: a case report.1992 May;35(5)

Conservative treatment of unruptured tubal pregnancy.1993 February;36(2)

Conservative management of cervical pregnancy.1993 July;36(7)

Two cases of cervical pregnancy treated with MIX chemotherapy.1993 July;36(7)

ABOUT

ARTICLE & TOPICS

Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES

POLICY

FOR CONTRIBUTORS

Editorial Office: 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea.
Tel: +82-2-2266-7238 Fax: +82-2-3445-2440 E-mail: journal@ogscience.org