| The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer. |
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Hye Sung Moon, Eun Ah Choi, Hye Won Chung |
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Department of Obstetrics & Gynecology, College of Medicine, and Medical Research Center, Korea. |
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| Abstract |
OBJECTIVES
Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors. METHODS: The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR). RESULTS: There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05). CONCLUSION: These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer. |
| Key Words:
IL-6, Cervical cancer, CIN, Carcinogenesis |
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