Toremifene-associated endometrial polyp: A case report and review of the literature.

Park, Eun Hee; Bahng, Sung Yun; Kim, Tae Sung; Mun, Seong Taek; Chung, Jib Kwang; Lee, Seok Min; Jin, So Young

Case Report

Korean Journal of Obstetrics & Gynecology 2002;45(7):1214-1217.
Published online July 1, 2002.

Toremifene-associated endometrial polyp: A case report and review of the literature.

Eun Hee Park, Sung Yun Bahng, Tae Sung Kim, Seong Taek Mun, Jib Kwang Chung, Seok Min Lee, So Young Jin

¹Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Seoul, Korea.
²Department of pathology, Soonchunhyang University College of Medicine, Seoul, Korea.

Abstract

Antiestrogens have been widely used in the treatment of breast cancer patients. Although tamoxifen is one of the most prevalent antiestrogens, some reported its hepatocarcinogenic effects and the long-term treatment may increase the risk of endometrial and gastrointestinal cancer. Toremifene is an interesting new antiestrogen and have a similar antitumor efficacy as tamoxifen, with less side-effect including less uterotrophic effect compared to tamoxifen, in mice. we report a case of endometrial polyp which were associated with toremifene use, in postmenopausal woman with breast cancer, with a brief review of literature.

Key Words: Toremifene, endometrial polyp