Expression of CD44S in benign, borderline, and malignant serous epithelial ovarian tumors.

Park, Seon Young; Shin, Min Jae; Lee, Yong Ho; Kim, Young Tae; Kim, In Sun; Lee, Kyu Wan

Original Article

Korean Journal of Obstetrics & Gynecology 2002;45(9):1465-1471.
Published online September 1, 2002.

Expression of CD44S in benign, borderline, and malignant serous epithelial ovarian tumors.

Seon Young Park, Min Jae Shin, Yong Ho Lee, Young Tae Kim, In Sun Kim, Kyu Wan Lee

¹Department of Obstetrics and Gynecology, School of Medicine, Korea University, Korea.
²Department of Pathology, School of Medicine, Korea University, Korea.

Abstract

OBJECTIVE
To determine the CD44S expression in the development and progression of serous ovarian tumor. METHODS: An immunohistochemical stain was undertaken of a series of 12 cases of benign, 15 cases of borderline, 30 cases of malignant serous ovarian tumors. Then, we analyzed the expression of CD44S to see whether expression of this adhesion molecule by tumor cells correlated with clinicopathological factors. RESULTS: In twelve benign tumors, CD44S was not expressed. Four of fifteen (27%) borderline tumors were positive for CD44S. Twelve of thirty (40%) malignant tumors were positive for CD44S. CD44S expression rate was significantly associated with non-benign tumors (P=0.003). But, there was no significant correlation between CD44S expression and stage, grade, peritoneal seeding or lymph node metastasis. CONCLUSION: Since benign ovarian tumors show negative CD44S, positive CD44S can provide partial diagnostic aid in ovarian malignant tumor.

Key Words: CD44S expression, Serous epithelial ovarian tumor