| Malignant gestational trophobalstic tumor with markedly elevated serum hCG levels and negative urine hCG level. |
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Hong Seop Kim, Ji Hyang Choi, Youn Kyung Park, Jung Hyun Beon, Youn Oh Kim, Dong Jin Kim, Beom Choi, Sook Cho |
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Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Korea. sookchomd@hanmail.net |
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| Abstract |
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Gestational trophoblastic disease comprises a spectrum of interrelated conditions originating from the placenta. Malignant gestational trophoblastic disease refers to lesions that have the potential for local invasion and metastasis. This compromises many histological entities including hydatidiform moles, invasive moles, gestational choriocarcinomas, and placental site trophoblastic tumors. Before the advent of sensitive assays for human chorionic gonadotropin (hCG) and efficacious chemotherapy, the morbidity and mortality from gestational trophoblastic disease were substantial. Currently, with sensitive quantitative assays for beta-hCG and current approaches to chemotherapy, most women with malignant trophoblastic disease can be cured. We present a case of malignant gestational trophobalstic tumor with serum beta-hCG concentration over 1million IU/L that metastaze to the lungs and have a hyperthyroidism, but negative urine hCG testing. We report a case with a brief review of literatures. |
| Key Words:
Urine hCG, Serum beta-hCG, Malignant Gestational trophobalstic tumor |
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