A case of ovarian large cell neuroendocrine carcinoma.

Lee, Jung Ju; Lee, Ju Ok; Lee, Dae Hyung; Kim, Mi Jin; Lee, Doo Jin

doi:2012.55.1.43

Obstet Gynecol Sci > Volume 55(1); 2012 > Article

Case Report

Korean Journal of Obstetrics & Gynecology 2012;55(1):43-46.
DOI: https://doi.org/10.5468/KJOG.2012.55.1.43 Published online January 1, 2012.

A case of ovarian large cell neuroendocrine carcinoma.

Jung Ju Lee, Ju Ok Lee, Dae Hyung Lee, Mi Jin Kim, Doo Jin Lee

¹Department of Obstetrics and Gynecology, Yeungnam University School of Medicine, Daegu, Korea. djlee@med.yu.ac.kr
²Department of Pathology, Yeungnam University School of Medicine, Daegu, Korea.

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare entity and is frequently associated with ovarian surface epithelial tumors. Since Collins et al. described the first case of mixed neuroendocrine and mucinous carcinoma, a few more cases of primary ovarian LCNECs have been reported. The prognosis of LCNECs is generally very poor even when the diagnosis is made at an early stage. A 40-year-old woman presented with a pelvic mass measuring 30 cm in diameter. She underwent an exploratory laparotomy for resection of the pelvic mass and staging if needed. After the operation, she was diagnosed of stage Ia LCNEC associated with mucinous tumor (including benign, borderline, malignant tumor) of left ovary. The patient received six cycles of paclitaxel-carboplatin chemotherapy postoperatively. There have been no signs of local tumor recurrence or metastasis at follow-up examinations during the first 8 months after the operation.

Key Words: Carcinoma, Neuroendocrine, Large cell type, Ovary